diff --git a/Source/Core/VideoBackends/Metal/MTLObjectCache.mm b/Source/Core/VideoBackends/Metal/MTLObjectCache.mm
index 48a8ad7dae..979c1b7627 100644
--- a/Source/Core/VideoBackends/Metal/MTLObjectCache.mm
+++ b/Source/Core/VideoBackends/Metal/MTLObjectCache.mm
@@ -418,6 +418,12 @@ public:
         // clang-format on
       }
       FramebufferState fs = config.framebuffer_state;
+      if (fs.color_texture_format == AbstractTextureFormat::Undefined &&
+          fs.depth_texture_format == AbstractTextureFormat::Undefined)
+      {
+        // Intel HD 4000's Metal driver asserts if you try to make one of these
+        PanicAlertFmt("Attempted to create pipeline with no render targets!");
+      }
       [desc setRasterSampleCount:fs.samples];
       [color0 setPixelFormat:Util::FromAbstract(fs.color_texture_format)];
       [desc setDepthAttachmentPixelFormat:Util::FromAbstract(fs.depth_texture_format)];
diff --git a/Source/Core/VideoCommon/PostProcessing.cpp b/Source/Core/VideoCommon/PostProcessing.cpp
index 69e4327bdd..0a1e995c15 100644
--- a/Source/Core/VideoCommon/PostProcessing.cpp
+++ b/Source/Core/VideoCommon/PostProcessing.cpp
@@ -709,6 +709,9 @@ bool PostProcessing::CompilePixelShader()
 
 bool PostProcessing::CompilePipeline()
 {
+  if (m_framebuffer_format == AbstractTextureFormat::Undefined)
+    return true;  // Not needed (some backends don't like making pipelines with no targets)
+
   AbstractPipelineConfig config = {};
   config.vertex_shader = m_vertex_shader.get();
   config.geometry_shader =
diff --git a/Source/Core/VideoCommon/RenderBase.cpp b/Source/Core/VideoCommon/RenderBase.cpp
index b4a40195c7..209fa8293a 100644
--- a/Source/Core/VideoCommon/RenderBase.cpp
+++ b/Source/Core/VideoCommon/RenderBase.cpp
@@ -1068,6 +1068,13 @@ bool Renderer::InitializeImGui()
 
 bool Renderer::RecompileImGuiPipeline()
 {
+  if (m_backbuffer_format == AbstractTextureFormat::Undefined)
+  {
+    // No backbuffer (nogui) means no imgui rendering will happen
+    // Some backends don't like making pipelines with no render targets
+    return true;
+  }
+
   std::unique_ptr<AbstractShader> vertex_shader =
       CreateShaderFromSource(ShaderStage::Vertex, FramebufferShaderGen::GenerateImGuiVertexShader(),
                              "ImGui vertex shader");