diff --git a/Source/Core/Core/Boot/Boot.cpp b/Source/Core/Core/Boot/Boot.cpp
index b56d7981cf..8dc65b1090 100644
--- a/Source/Core/Core/Boot/Boot.cpp
+++ b/Source/Core/Core/Boot/Boot.cpp
@@ -436,11 +436,7 @@ bool CBoot::BootUp(std::unique_ptr<BootParameters> boot)
       if (!EmulatedBS2(config.bWii, *volume))
         return false;
 
-      // Try to load the symbol map if there is one, and then scan it for
-      // and eventually replace code
-      if (LoadMapFromFilename())
-        HLE::PatchFunctions();
-
+      SConfig::OnNewTitleLoad();
       return true;
     }
 
@@ -482,9 +478,11 @@ bool CBoot::BootUp(std::unique_ptr<BootParameters> boot)
         SetupGCMemory();
       }
 
+      SConfig::OnNewTitleLoad();
+
       PC = executable.reader->GetEntryPoint();
 
-      if (executable.reader->LoadSymbols() || LoadMapFromFilename())
+      if (executable.reader->LoadSymbols())
       {
         UpdateDebugger_MapLoaded();
         HLE::PatchFunctions();
@@ -495,13 +493,21 @@ bool CBoot::BootUp(std::unique_ptr<BootParameters> boot)
     bool operator()(const DiscIO::VolumeWAD& wad) const
     {
       SetDefaultDisc();
-      return Boot_WiiWAD(wad);
+      if (!Boot_WiiWAD(wad))
+        return false;
+
+      SConfig::OnNewTitleLoad();
+      return true;
     }
 
     bool operator()(const BootParameters::NANDTitle& nand_title) const
     {
       SetDefaultDisc();
-      return BootNANDTitle(nand_title.id);
+      if (!BootNANDTitle(nand_title.id))
+        return false;
+
+      SConfig::OnNewTitleLoad();
+      return true;
     }
 
     bool operator()(const BootParameters::IPL& ipl) const
@@ -525,9 +531,7 @@ bool CBoot::BootUp(std::unique_ptr<BootParameters> boot)
         SetDisc(DiscIO::CreateDisc(ipl.disc->path), ipl.disc->auto_disc_change_paths);
       }
 
-      if (LoadMapFromFilename())
-        HLE::PatchFunctions();
-
+      SConfig::OnNewTitleLoad();
       return true;
     }
 
@@ -544,8 +548,6 @@ bool CBoot::BootUp(std::unique_ptr<BootParameters> boot)
   if (!std::visit(BootTitle(), boot->parameters))
     return false;
 
-  PatchEngine::LoadPatches();
-  HLE::PatchFixedFunctions();
   return true;
 }
 
diff --git a/Source/Core/Core/ConfigManager.cpp b/Source/Core/Core/ConfigManager.cpp
index accc958615..d4ec804b3a 100644
--- a/Source/Core/Core/ConfigManager.cpp
+++ b/Source/Core/Core/ConfigManager.cpp
@@ -706,19 +706,23 @@ void SConfig::SetRunningGameMetadata(const std::string& game_id, const std::stri
   Config::AddLayer(ConfigLoaders::GenerateLocalGameConfigLoader(game_id, revision));
 
   if (Core::IsRunning())
-  {
-    // TODO: have a callback mechanism for title changes?
-    if (!g_symbolDB.IsEmpty())
-    {
-      g_symbolDB.Clear();
-      Host_NotifyMapLoaded();
-    }
-    CBoot::LoadMapFromFilename();
-    HLE::Reload();
-    PatchEngine::Reload();
-    HiresTexture::Update();
     DolphinAnalytics::Instance().ReportGameStart();
+}
+
+void SConfig::OnNewTitleLoad()
+{
+  if (!Core::IsRunning())
+    return;
+
+  if (!g_symbolDB.IsEmpty())
+  {
+    g_symbolDB.Clear();
+    Host_NotifyMapLoaded();
   }
+  CBoot::LoadMapFromFilename();
+  HLE::Reload();
+  PatchEngine::Reload();
+  HiresTexture::Update();
 }
 
 void SConfig::LoadDefaults()
diff --git a/Source/Core/Core/ConfigManager.h b/Source/Core/Core/ConfigManager.h
index d1de769706..8d67d35ffd 100644
--- a/Source/Core/Core/ConfigManager.h
+++ b/Source/Core/Core/ConfigManager.h
@@ -197,6 +197,10 @@ struct SConfig
   void SetRunningGameMetadata(const DiscIO::Volume& volume, const DiscIO::Partition& partition);
   void SetRunningGameMetadata(const IOS::ES::TMDReader& tmd, DiscIO::Platform platform);
   void SetRunningGameMetadata(const std::string& game_id);
+  // Reloads title-specific map files, patches, custom textures, etc.
+  // This should only be called after the new title has been loaded into memory.
+  static void OnNewTitleLoad();
+
   void LoadDefaults();
   static std::string MakeGameID(std::string_view file_name);
   // Replaces NTSC-K with some other region, and doesn't replace non-NTSC-K regions
diff --git a/Source/Core/Core/IOS/IOS.cpp b/Source/Core/Core/IOS/IOS.cpp
index d5a26a06e1..b7b5a34e15 100644
--- a/Source/Core/Core/IOS/IOS.cpp
+++ b/Source/Core/Core/IOS/IOS.cpp
@@ -856,6 +856,7 @@ IOSC& Kernel::GetIOSC()
 static void FinishPPCBootstrap(u64 userdata, s64 cycles_late)
 {
   ReleasePPC();
+  SConfig::OnNewTitleLoad();
   INFO_LOG_FMT(IOS, "Bootstrapping done.");
 }