diff --git a/Source/Core/VideoBackends/Vulkan/Renderer.cpp b/Source/Core/VideoBackends/Vulkan/Renderer.cpp
index 3037e3e5f4..5f79897842 100644
--- a/Source/Core/VideoBackends/Vulkan/Renderer.cpp
+++ b/Source/Core/VideoBackends/Vulkan/Renderer.cpp
@@ -33,6 +33,7 @@
 #include "VideoCommon/AVIDump.h"
 #include "VideoCommon/BPFunctions.h"
 #include "VideoCommon/BPMemory.h"
+#include "VideoCommon/DriverDetails.h"
 #include "VideoCommon/OnScreenDisplay.h"
 #include "VideoCommon/PixelEngine.h"
 #include "VideoCommon/PixelShaderManager.h"
@@ -391,6 +392,8 @@ void Renderer::ClearScreen(const EFBRectangle& rc, bool color_enable, bool alpha
 
   // Fast path: Use vkCmdClearAttachments to clear the buffers within a render path
   // We can't use this when preserving alpha but clearing color.
+  if (g_ActiveConfig.iMultisamples == 1 ||
+      !DriverDetails::HasBug(DriverDetails::BUG_BROKEN_MSAA_VKCMDCLEARATTACHMENTS))
   {
     VkClearAttachment clear_attachments[2];
     uint32_t num_clear_attachments = 0;
diff --git a/Source/Core/VideoCommon/DriverDetails.cpp b/Source/Core/VideoCommon/DriverDetails.cpp
index fb12fc04b8..8db1a595b8 100644
--- a/Source/Core/VideoCommon/DriverDetails.cpp
+++ b/Source/Core/VideoCommon/DriverDetails.cpp
@@ -101,7 +101,9 @@ static BugInfo m_known_bugs[] = {
     {API_OPENGL, OS_LINUX, VENDOR_MESA, DRIVER_I965, Family::UNKNOWN,
      BUG_SHARED_CONTEXT_SHADER_COMPILATION, -1.0, -1.0, true},
     {API_OPENGL, OS_LINUX, VENDOR_MESA, DRIVER_NOUVEAU, Family::UNKNOWN,
-     BUG_SHARED_CONTEXT_SHADER_COMPILATION, -1.0, -1.0, true}};
+     BUG_SHARED_CONTEXT_SHADER_COMPILATION, -1.0, -1.0, true},
+    {API_VULKAN, OS_ALL, VENDOR_NVIDIA, DRIVER_NVIDIA, Family::UNKNOWN,
+     BUG_BROKEN_MSAA_VKCMDCLEARATTACHMENTS, -1.0, -1.0, true}};
 
 static std::map<Bug, BugInfo> m_bugs;
 
diff --git a/Source/Core/VideoCommon/DriverDetails.h b/Source/Core/VideoCommon/DriverDetails.h
index d256b51918..a57071ef68 100644
--- a/Source/Core/VideoCommon/DriverDetails.h
+++ b/Source/Core/VideoCommon/DriverDetails.h
@@ -253,6 +253,12 @@ enum Bug
   // Started version: -1
   // Ended Version: -1
   BUG_SHARED_CONTEXT_SHADER_COMPILATION,
+
+  // Bug: vkCmdClearAttachments with MSAA enabled causes NVIDIA Maxwell+ cards to lock up.
+  // Started version: -1
+  // Ended version: -1
+  // Seems to only occur when the top of the clear rect is non-zero.
+  BUG_BROKEN_MSAA_VKCMDCLEARATTACHMENTS,
 };
 
 // Initializes our internal vendor, device family, and driver version