diff --git a/Source/Core/VideoCommon/DriverDetails.cpp b/Source/Core/VideoCommon/DriverDetails.cpp
index aa186181cb..301c73d89f 100644
--- a/Source/Core/VideoCommon/DriverDetails.cpp
+++ b/Source/Core/VideoCommon/DriverDetails.cpp
@@ -88,6 +88,8 @@ static BugInfo m_known_bugs[] = {
      -1.0, true},
     {API_OPENGL, OS_ALL, VENDOR_MESA, DRIVER_I965, Family::UNKNOWN, BUG_BROKEN_CLIP_DISTANCE, -1.0,
      -1.0, true},
+    {API_VULKAN, OS_ALL, VENDOR_ATI, DRIVER_ATI, Family::UNKNOWN,
+     BUG_BROKEN_FRAGMENT_SHADER_INDEX_DECORATION, -1.0, -1.0, true},
     {API_OPENGL, OS_WINDOWS, VENDOR_ATI, DRIVER_ATI, Family::UNKNOWN,
      BUG_BROKEN_DUAL_SOURCE_BLENDING, -1.0, -1.0, true},
     {API_OPENGL, OS_OSX, VENDOR_INTEL, DRIVER_INTEL, Family::UNKNOWN,
diff --git a/Source/Core/VideoCommon/DriverDetails.h b/Source/Core/VideoCommon/DriverDetails.h
index f3673a26f2..9ace5f83b4 100644
--- a/Source/Core/VideoCommon/DriverDetails.h
+++ b/Source/Core/VideoCommon/DriverDetails.h
@@ -220,6 +220,14 @@ enum Bug
   // the gl_ClipDistance inputs from the vertex shader.
   BUG_BROKEN_CLIP_DISTANCE,
 
+  // Bug: Dual-source outputs from fragment shaders are broken on AMD Vulkan drivers
+  // Started Version: -1
+  // Ended Version: -1
+  // Fragment shaders that specify dual-source outputs, via layout(location = 0, index = ...) cause
+  // the driver to fail to create graphics pipelines. The workaround for this is to specify the
+  // index as a MRT location instead, or omit the binding completely.
+  BUG_BROKEN_FRAGMENT_SHADER_INDEX_DECORATION,
+
   // Bug: Dual-source outputs from fragment shaders are broken on AMD OpenGL drivers
   // Started Version: -1
   // Ended Version: -1
diff --git a/Source/Core/VideoCommon/PixelShaderGen.cpp b/Source/Core/VideoCommon/PixelShaderGen.cpp
index 115d42f14c..7ba5edba7f 100644
--- a/Source/Core/VideoCommon/PixelShaderGen.cpp
+++ b/Source/Core/VideoCommon/PixelShaderGen.cpp
@@ -553,8 +553,16 @@ ShaderCode GeneratePixelShaderCode(APIType ApiType, const ShaderHostConfig& host
   {
     if (use_dual_source)
     {
-      out.Write("FRAGMENT_OUTPUT_LOCATION_INDEXED(0, 0) out vec4 ocol0;\n");
-      out.Write("FRAGMENT_OUTPUT_LOCATION_INDEXED(0, 1) out vec4 ocol1;\n");
+      if (DriverDetails::HasBug(DriverDetails::BUG_BROKEN_FRAGMENT_SHADER_INDEX_DECORATION))
+      {
+        out.Write("FRAGMENT_OUTPUT_LOCATION(0) out vec4 ocol0;\n");
+        out.Write("FRAGMENT_OUTPUT_LOCATION(1) out vec4 ocol1;\n");
+      }
+      else
+      {
+        out.Write("FRAGMENT_OUTPUT_LOCATION_INDEXED(0, 0) out vec4 ocol0;\n");
+        out.Write("FRAGMENT_OUTPUT_LOCATION_INDEXED(0, 1) out vec4 ocol1;\n");
+      }
     }
     else if (use_shader_blend)
     {
@@ -562,7 +570,14 @@ ShaderCode GeneratePixelShaderCode(APIType ApiType, const ShaderHostConfig& host
       // intermediate value with multiple reads & modifications, so pull out the "real" output value
       // and use a temporary for calculations, then set the output value once at the end of the
       // shader
-      out.Write("FRAGMENT_OUTPUT_LOCATION_INDEXED(0, 0) FRAGMENT_INOUT vec4 real_ocol0;\n");
+      if (DriverDetails::HasBug(DriverDetails::BUG_BROKEN_FRAGMENT_SHADER_INDEX_DECORATION))
+      {
+        out.Write("FRAGMENT_OUTPUT_LOCATION(0) FRAGMENT_INOUT vec4 real_ocol0;\n");
+      }
+      else
+      {
+        out.Write("FRAGMENT_OUTPUT_LOCATION_INDEXED(0, 0) FRAGMENT_INOUT vec4 real_ocol0;\n");
+      }
     }
     else
     {
diff --git a/Source/Core/VideoCommon/UberShaderPixel.cpp b/Source/Core/VideoCommon/UberShaderPixel.cpp
index cd188d4de9..9c9630886a 100644
--- a/Source/Core/VideoCommon/UberShaderPixel.cpp
+++ b/Source/Core/VideoCommon/UberShaderPixel.cpp
@@ -69,8 +69,16 @@ ShaderCode GenPixelShader(APIType ApiType, const ShaderHostConfig& host_config,
   {
     if (use_dual_source)
     {
-      out.Write("FRAGMENT_OUTPUT_LOCATION_INDEXED(0, 0) out vec4 ocol0;\n");
-      out.Write("FRAGMENT_OUTPUT_LOCATION_INDEXED(0, 1) out vec4 ocol1;\n");
+      if (DriverDetails::HasBug(DriverDetails::BUG_BROKEN_FRAGMENT_SHADER_INDEX_DECORATION))
+      {
+        out.Write("FRAGMENT_OUTPUT_LOCATION(0) out vec4 ocol0;\n");
+        out.Write("FRAGMENT_OUTPUT_LOCATION(1) out vec4 ocol1;\n");
+      }
+      else
+      {
+        out.Write("FRAGMENT_OUTPUT_LOCATION_INDEXED(0, 0) out vec4 ocol0;\n");
+        out.Write("FRAGMENT_OUTPUT_LOCATION_INDEXED(0, 1) out vec4 ocol1;\n");
+      }
     }
     else if (use_shader_blend)
     {
@@ -78,7 +86,14 @@ ShaderCode GenPixelShader(APIType ApiType, const ShaderHostConfig& host_config,
       // intermediate value with multiple reads & modifications, so pull out the "real" output value
       // and use a temporary for calculations, then set the output value once at the end of the
       // shader
-      out.Write("FRAGMENT_OUTPUT_LOCATION_INDEXED(0, 0) FRAGMENT_INOUT vec4 real_ocol0;\n");
+      if (DriverDetails::HasBug(DriverDetails::BUG_BROKEN_FRAGMENT_SHADER_INDEX_DECORATION))
+      {
+        out.Write("FRAGMENT_OUTPUT_LOCATION(0) FRAGMENT_INOUT vec4 real_ocol0;\n");
+      }
+      else
+      {
+        out.Write("FRAGMENT_OUTPUT_LOCATION_INDEXED(0, 0) FRAGMENT_INOUT vec4 real_ocol0;\n");
+      }
     }
     else
     {