diff --git a/Source/Core/VideoCommon/GeometryShaderGen.cpp b/Source/Core/VideoCommon/GeometryShaderGen.cpp
index 99e546a363..90b9d01e16 100644
--- a/Source/Core/VideoCommon/GeometryShaderGen.cpp
+++ b/Source/Core/VideoCommon/GeometryShaderGen.cpp
@@ -55,7 +55,7 @@ ShaderCode GenerateGeometryShaderCode(APIType ApiType, const geometry_shader_uid
   if (uid_data->wireframe)
     vertex_out++;
 
-  if (ApiType == APIType::OpenGL)
+  if (ApiType == APIType::OpenGL || ApiType == APIType::Vulkan)
   {
     // Insert layout parameters
     if (g_ActiveConfig.backend_info.bSupportsGSInstancing)
@@ -77,10 +77,11 @@ ShaderCode GenerateGeometryShaderCode(APIType ApiType, const geometry_shader_uid
   out.Write("%s", s_lighting_struct);
 
   // uniforms
-  if (ApiType == APIType::OpenGL)
+  if (ApiType == APIType::OpenGL || ApiType == APIType::Vulkan)
     out.Write("UBO_BINDING(std140, 3) uniform GSBlock {\n");
   else
     out.Write("cbuffer GSBlock {\n");
+
   out.Write("\tfloat4 " I_STEREOPARAMS ";\n"
             "\tfloat4 " I_LINEPTPARAMS ";\n"
             "\tint4 " I_TEXOFFSET ";\n"
@@ -91,7 +92,7 @@ ShaderCode GenerateGeometryShaderCode(APIType ApiType, const geometry_shader_uid
                                       "");
   out.Write("};\n");
 
-  if (ApiType == APIType::OpenGL)
+  if (ApiType == APIType::OpenGL || ApiType == APIType::Vulkan)
   {
     if (g_ActiveConfig.backend_info.bSupportsGSInstancing)
       out.Write("#define InstanceID gl_InvocationID\n");
@@ -145,7 +146,7 @@ ShaderCode GenerateGeometryShaderCode(APIType ApiType, const geometry_shader_uid
 
   if (uid_data->primitive_type == PRIMITIVE_LINES)
   {
-    if (ApiType == APIType::OpenGL)
+    if (ApiType == APIType::OpenGL || ApiType == APIType::Vulkan)
     {
       out.Write("\tVS_OUTPUT start, end;\n");
       AssignVSOutputMembers(out, "start", "vs[0]", uid_data->numTexGens, uid_data->pixel_lighting);
@@ -176,7 +177,7 @@ ShaderCode GenerateGeometryShaderCode(APIType ApiType, const geometry_shader_uid
   }
   else if (uid_data->primitive_type == PRIMITIVE_POINTS)
   {
-    if (ApiType == APIType::OpenGL)
+    if (ApiType == APIType::OpenGL || ApiType == APIType::Vulkan)
     {
       out.Write("\tVS_OUTPUT center;\n");
       AssignVSOutputMembers(out, "center", "vs[0]", uid_data->numTexGens, uid_data->pixel_lighting);
@@ -207,7 +208,7 @@ ShaderCode GenerateGeometryShaderCode(APIType ApiType, const geometry_shader_uid
 
   out.Write("\tfor (int i = 0; i < %d; ++i) {\n", vertex_in);
 
-  if (ApiType == APIType::OpenGL)
+  if (ApiType == APIType::OpenGL || ApiType == APIType::Vulkan)
   {
     out.Write("\tVS_OUTPUT f;\n");
     AssignVSOutputMembers(out, "f", "vs[i]", uid_data->numTexGens, uid_data->pixel_lighting);
@@ -230,7 +231,7 @@ ShaderCode GenerateGeometryShaderCode(APIType ApiType, const geometry_shader_uid
   {
     // Select the output layer
     out.Write("\tps.layer = eye;\n");
-    if (ApiType == APIType::OpenGL)
+    if (ApiType == APIType::OpenGL || ApiType == APIType::Vulkan)
       out.Write("\tgl_Layer = eye;\n");
 
     // For stereoscopy add a small horizontal offset in Normalized Device Coordinates proportional
@@ -329,12 +330,19 @@ static void EmitVertex(ShaderCode& out, const geometry_shader_uid_data* uid_data
     }
     AssignVSOutputMembers(out, "ps", vertex, uid_data->numTexGens, uid_data->pixel_lighting);
   }
+  else if (ApiType == APIType::Vulkan)
+  {
+    // Vulkan NDC space has Y pointing down (right-handed NDC space).
+    out.Write("\tgl_Position = %s.pos;\n", vertex);
+    out.Write("\tgl_Position.y = -gl_Position.y;\n");
+    AssignVSOutputMembers(out, "ps", vertex, uid_data->numTexGens, uid_data->pixel_lighting);
+  }
   else
   {
     out.Write("\tps.o = %s;\n", vertex);
   }
 
-  if (ApiType == APIType::OpenGL)
+  if (ApiType == APIType::OpenGL || ApiType == APIType::Vulkan)
     out.Write("\tEmitVertex();\n");
   else
     out.Write("\toutput.Append(ps);\n");
@@ -345,7 +353,7 @@ static void EndPrimitive(ShaderCode& out, const geometry_shader_uid_data* uid_da
   if (uid_data->wireframe)
     EmitVertex(out, uid_data, "first", ApiType);
 
-  if (ApiType == APIType::OpenGL)
+  if (ApiType == APIType::OpenGL || ApiType == APIType::Vulkan)
     out.Write("\tEndPrimitive();\n");
   else
     out.Write("\toutput.RestartStrip();\n");
diff --git a/Source/Core/VideoCommon/PixelShaderGen.cpp b/Source/Core/VideoCommon/PixelShaderGen.cpp
index 65722fb7d4..4038d9329c 100644
--- a/Source/Core/VideoCommon/PixelShaderGen.cpp
+++ b/Source/Core/VideoCommon/PixelShaderGen.cpp
@@ -384,6 +384,17 @@ ShaderCode GeneratePixelShaderCode(DSTALPHA_MODE dstAlphaMode, APIType ApiType,
   {
     out.Write("SAMPLER_BINDING(0) uniform sampler2DArray samp[8];\n");
   }
+  else if (ApiType == APIType::Vulkan)
+  {
+    out.Write("SAMPLER_BINDING(0) uniform sampler2DArray samp0;\n");
+    out.Write("SAMPLER_BINDING(1) uniform sampler2DArray samp1;\n");
+    out.Write("SAMPLER_BINDING(2) uniform sampler2DArray samp2;\n");
+    out.Write("SAMPLER_BINDING(3) uniform sampler2DArray samp3;\n");
+    out.Write("SAMPLER_BINDING(4) uniform sampler2DArray samp4;\n");
+    out.Write("SAMPLER_BINDING(5) uniform sampler2DArray samp5;\n");
+    out.Write("SAMPLER_BINDING(6) uniform sampler2DArray samp6;\n");
+    out.Write("SAMPLER_BINDING(7) uniform sampler2DArray samp7;\n");
+  }
   else  // D3D
   {
     // Declare samplers
@@ -393,7 +404,7 @@ ShaderCode GeneratePixelShaderCode(DSTALPHA_MODE dstAlphaMode, APIType ApiType,
   }
   out.Write("\n");
 
-  if (ApiType == APIType::OpenGL)
+  if (ApiType == APIType::OpenGL || ApiType == APIType::Vulkan)
     out.Write("UBO_BINDING(std140, 1) uniform PSBlock {\n");
   else
     out.Write("cbuffer PSBlock : register(b0) {\n");
@@ -416,7 +427,7 @@ ShaderCode GeneratePixelShaderCode(DSTALPHA_MODE dstAlphaMode, APIType ApiType,
   {
     out.Write("%s", s_lighting_struct);
 
-    if (ApiType == APIType::OpenGL)
+    if (ApiType == APIType::OpenGL || ApiType == APIType::Vulkan)
       out.Write("UBO_BINDING(std140, 2) uniform VSBlock {\n");
     else
       out.Write("cbuffer VSBlock : register(b1) {\n");
@@ -427,7 +438,7 @@ ShaderCode GeneratePixelShaderCode(DSTALPHA_MODE dstAlphaMode, APIType ApiType,
 
   if (uid_data->bounding_box)
   {
-    if (ApiType == APIType::OpenGL)
+    if (ApiType == APIType::OpenGL || ApiType == APIType::Vulkan)
     {
       out.Write("SSBO_BINDING(0) buffer BBox {\n"
                 "\tint4 bbox_data;\n"
@@ -480,7 +491,7 @@ ShaderCode GeneratePixelShaderCode(DSTALPHA_MODE dstAlphaMode, APIType ApiType,
     // ARB_image_load_store extension yet.
 
     // D3D11 also has a way to force the driver to enable early-z, so we're fine here.
-    if (ApiType == APIType::OpenGL)
+    if (ApiType == APIType::OpenGL || ApiType == APIType::Vulkan)
     {
       // This is a #define which signals whatever early-z method the driver supports.
       out.Write("FORCE_EARLY_Z; \n");
@@ -502,7 +513,7 @@ ShaderCode GeneratePixelShaderCode(DSTALPHA_MODE dstAlphaMode, APIType ApiType,
     warn_once = false;
   }
 
-  if (ApiType == APIType::OpenGL)
+  if (ApiType == APIType::OpenGL || ApiType == APIType::Vulkan)
   {
     if (dstAlphaMode == DSTALPHA_DUAL_SOURCE_BLEND)
     {
@@ -517,7 +528,8 @@ ShaderCode GeneratePixelShaderCode(DSTALPHA_MODE dstAlphaMode, APIType ApiType,
     if (uid_data->per_pixel_depth)
       out.Write("#define depth gl_FragDepth\n");
 
-    if (g_ActiveConfig.backend_info.bSupportsGeometryShaders)
+    // We need to always use output blocks for Vulkan, but geometry shaders are also optional.
+    if (g_ActiveConfig.backend_info.bSupportsGeometryShaders || ApiType == APIType::Vulkan)
     {
       out.Write("VARYING_LOCATION(0) in VertexData {\n");
       GenerateVSOutputMembers(
@@ -555,7 +567,7 @@ ShaderCode GeneratePixelShaderCode(DSTALPHA_MODE dstAlphaMode, APIType ApiType,
 
     out.Write("void main()\n{\n");
 
-    if (g_ActiveConfig.backend_info.bSupportsGeometryShaders)
+    if (g_ActiveConfig.backend_info.bSupportsGeometryShaders || ApiType == APIType::Vulkan)
     {
       for (unsigned int i = 0; i < uid_data->genMode_numtexgens; ++i)
         out.Write("\tfloat3 uv%d = tex%d;\n", i, i);
@@ -726,7 +738,7 @@ ShaderCode GeneratePixelShaderCode(DSTALPHA_MODE dstAlphaMode, APIType ApiType,
   }
   else
   {
-    if (ApiType == APIType::D3D)
+    if (ApiType == APIType::D3D || ApiType == APIType::Vulkan)
       out.Write("\tint zCoord = int((1.0 - rawpos.z) * 16777216.0);\n");
     else
       out.Write("\tint zCoord = int(rawpos.z * 16777216.0);\n");
@@ -740,7 +752,7 @@ ShaderCode GeneratePixelShaderCode(DSTALPHA_MODE dstAlphaMode, APIType ApiType,
   // Note: z-textures are not written to depth buffer if early depth test is used
   if (uid_data->per_pixel_depth && uid_data->early_ztest)
   {
-    if (ApiType == APIType::D3D)
+    if (ApiType == APIType::D3D || ApiType == APIType::Vulkan)
       out.Write("\tdepth = 1.0 - float(zCoord) / 16777216.0;\n");
     else
       out.Write("\tdepth = float(zCoord) / 16777216.0;\n");
@@ -761,7 +773,7 @@ ShaderCode GeneratePixelShaderCode(DSTALPHA_MODE dstAlphaMode, APIType ApiType,
 
   if (uid_data->per_pixel_depth && uid_data->late_ztest)
   {
-    if (ApiType == APIType::D3D)
+    if (ApiType == APIType::D3D || ApiType == APIType::Vulkan)
       out.Write("\tdepth = 1.0 - float(zCoord) / 16777216.0;\n");
     else
       out.Write("\tdepth = float(zCoord) / 16777216.0;\n");
@@ -791,7 +803,8 @@ ShaderCode GeneratePixelShaderCode(DSTALPHA_MODE dstAlphaMode, APIType ApiType,
 
   if (uid_data->bounding_box)
   {
-    const char* atomic_op = ApiType == APIType::OpenGL ? "atomic" : "Interlocked";
+    const char* atomic_op =
+        (ApiType == APIType::OpenGL || ApiType == APIType::Vulkan) ? "atomic" : "Interlocked";
     out.Write("\tif(bbox_data[0] > int(rawpos.x)) %sMin(bbox_data[0], int(rawpos.x));\n"
               "\tif(bbox_data[1] < int(rawpos.x)) %sMax(bbox_data[1], int(rawpos.x));\n"
               "\tif(bbox_data[2] > int(rawpos.y)) %sMin(bbox_data[2], int(rawpos.y));\n"
@@ -1138,12 +1151,21 @@ static void SampleTexture(ShaderCode& out, const char* texcoords, const char* te
   out.SetConstantsUsed(C_TEXDIMS + texmap, C_TEXDIMS + texmap);
 
   if (ApiType == APIType::D3D)
+  {
     out.Write("iround(255.0 * Tex[%d].Sample(samp[%d], float3(%s.xy * " I_TEXDIMS
               "[%d].xy, %s))).%s;\n",
               texmap, texmap, texcoords, texmap, stereo ? "layer" : "0.0", texswap);
+  }
+  else if (ApiType == APIType::Vulkan)
+  {
+    out.Write("iround(255.0 * texture(samp%d, float3(%s.xy * " I_TEXDIMS "[%d].xy, %s))).%s;\n",
+              texmap, texcoords, texmap, stereo ? "layer" : "0.0", texswap);
+  }
   else
+  {
     out.Write("iround(255.0 * texture(samp[%d], float3(%s.xy * " I_TEXDIMS "[%d].xy, %s))).%s;\n",
               texmap, texcoords, texmap, stereo ? "layer" : "0.0", texswap);
+  }
 }
 
 static const char* tevAlphaFuncsTable[] = {
@@ -1195,7 +1217,10 @@ static void WriteAlphaTest(ShaderCode& out, const pixel_shader_uid_data* uid_dat
   if (dstAlphaMode == DSTALPHA_DUAL_SOURCE_BLEND)
     out.Write("\t\tocol1 = float4(0.0, 0.0, 0.0, 0.0);\n");
   if (per_pixel_depth)
-    out.Write("\t\tdepth = %s;\n", (ApiType == APIType::D3D) ? "0.0" : "1.0");
+  {
+    out.Write("\t\tdepth = %s;\n",
+              (ApiType == APIType::D3D || ApiType == APIType::Vulkan) ? "0.0" : "1.0");
+  }
 
   // ZCOMPLOC HACK:
   if (!uid_data->alpha_test_use_zcomploc_hack)
diff --git a/Source/Core/VideoCommon/TextureConversionShader.cpp b/Source/Core/VideoCommon/TextureConversionShader.cpp
index 16ea016675..bd4e1349df 100644
--- a/Source/Core/VideoCommon/TextureConversionShader.cpp
+++ b/Source/Core/VideoCommon/TextureConversionShader.cpp
@@ -81,7 +81,10 @@ static void WriteSwizzler(char*& p, u32 format, APIType ApiType)
 {
   // left, top, of source rectangle within source texture
   // width of the destination rectangle, scale_factor (1 or 2)
-  WRITE(p, "uniform int4 position;\n");
+  if (ApiType == APIType::Vulkan)
+    WRITE(p, "layout(std140, push_constant) uniform PCBlock { int4 position; } PC;\n");
+  else
+    WRITE(p, "uniform int4 position;\n");
 
   int blkW = TexDecoder_GetBlockWidthInTexels(format);
   int blkH = TexDecoder_GetBlockHeightInTexels(format);
@@ -98,6 +101,17 @@ static void WriteSwizzler(char*& p, u32 format, APIType ApiType)
              "  int2 sampleUv;\n"
              "  int2 uv1 = int2(gl_FragCoord.xy);\n");
   }
+  else if (ApiType == APIType::Vulkan)
+  {
+    WRITE(p, "SAMPLER_BINDING(0) uniform sampler2DArray samp0;\n");
+    WRITE(p, "FRAGMENT_OUTPUT_LOCATION(0) out vec4 ocol0;\n");
+
+    WRITE(p, "void main()\n");
+    WRITE(p, "{\n"
+             "  int2 sampleUv;\n"
+             "  int2 uv1 = int2(gl_FragCoord.xy);\n"
+             "  int4 position = PC.position;\n");
+  }
   else  // D3D
   {
     WRITE(p, "sampler samp0 : register(s0);\n");
@@ -146,7 +160,7 @@ static void WriteSwizzler(char*& p, u32 format, APIType ApiType)
 static void WriteSampleColor(char*& p, const char* colorComp, const char* dest, int xoffset,
                              APIType ApiType, bool depth = false)
 {
-  if (ApiType == APIType::OpenGL)
+  if (ApiType == APIType::OpenGL || ApiType == APIType::Vulkan)
   {
     WRITE(p, "  %s = texture(samp0, float3(uv0 + float2(%d, 0) * sample_offset, 0.0)).%s;\n", dest,
           xoffset, colorComp);
@@ -155,7 +169,10 @@ static void WriteSampleColor(char*& p, const char* colorComp, const char* dest,
   {
     WRITE(p, "  %s = Tex0.Sample(samp0, float3(uv0 + float2(%d, 0) * sample_offset, 0.0)).%s;\n",
           dest, xoffset, colorComp);
+  }
 
+  if (ApiType == APIType::D3D || ApiType == APIType::Vulkan)
+  {
     // Handle D3D depth inversion.
     if (depth)
       WRITE(p, "  %s = 1.0 - %s;\n", dest, dest);
diff --git a/Source/Core/VideoCommon/VertexShaderGen.cpp b/Source/Core/VideoCommon/VertexShaderGen.cpp
index 4801bc4797..7725331193 100644
--- a/Source/Core/VideoCommon/VertexShaderGen.cpp
+++ b/Source/Core/VideoCommon/VertexShaderGen.cpp
@@ -85,10 +85,11 @@ ShaderCode GenerateVertexShaderCode(APIType api_type, const vertex_shader_uid_da
   out.Write("%s", s_lighting_struct);
 
   // uniforms
-  if (api_type == APIType::OpenGL)
+  if (api_type == APIType::OpenGL || api_type == APIType::Vulkan)
     out.Write("UBO_BINDING(std140, 2) uniform VSBlock {\n");
   else
     out.Write("cbuffer VSBlock {\n");
+
   out.Write(s_shader_uniforms);
   out.Write("};\n");
 
@@ -96,7 +97,7 @@ ShaderCode GenerateVertexShaderCode(APIType api_type, const vertex_shader_uid_da
   GenerateVSOutputMembers(out, api_type, uid_data->numTexGens, uid_data->pixel_lighting, "");
   out.Write("};\n");
 
-  if (api_type == APIType::OpenGL)
+  if (api_type == APIType::OpenGL || api_type == APIType::Vulkan)
   {
     out.Write("ATTRIBUTE_LOCATION(%d) in float4 rawpos;\n", SHADER_POSITION_ATTRIB);
     if (uid_data->components & VB_HAS_POSMTXIDX)
@@ -123,7 +124,8 @@ ShaderCode GenerateVertexShaderCode(APIType api_type, const vertex_shader_uid_da
       }
     }
 
-    if (g_ActiveConfig.backend_info.bSupportsGeometryShaders)
+    // We need to always use output blocks for Vulkan, but geometry shaders are also optional.
+    if (g_ActiveConfig.backend_info.bSupportsGeometryShaders || api_type == APIType::Vulkan)
     {
       out.Write("VARYING_LOCATION(0) out VertexData {\n");
       GenerateVSOutputMembers(
@@ -463,9 +465,9 @@ ShaderCode GenerateVertexShaderCode(APIType api_type, const vertex_shader_uid_da
   // get rasterized correctly.
   out.Write("o.pos.xy = o.pos.xy - o.pos.w * " I_PIXELCENTERCORRECTION ".xy;\n");
 
-  if (api_type == APIType::OpenGL)
+  if (api_type == APIType::OpenGL || api_type == APIType::Vulkan)
   {
-    if (g_ActiveConfig.backend_info.bSupportsGeometryShaders)
+    if (g_ActiveConfig.backend_info.bSupportsGeometryShaders || api_type == APIType::Vulkan)
     {
       AssignVSOutputMembers(out, "vs", "o", uid_data->numTexGens, uid_data->pixel_lighting);
     }
@@ -490,7 +492,12 @@ ShaderCode GenerateVertexShaderCode(APIType api_type, const vertex_shader_uid_da
       out.Write("gl_ClipDistance[0] = o.clipDist0;\n");
       out.Write("gl_ClipDistance[1] = o.clipDist1;\n");
     }
-    out.Write("gl_Position = o.pos;\n");
+
+    // Vulkan NDC space has Y pointing down (right-handed NDC space).
+    if (api_type == APIType::Vulkan)
+      out.Write("gl_Position = float4(o.pos.x, -o.pos.y, o.pos.z, o.pos.w);\n");
+    else
+      out.Write("gl_Position = o.pos;\n");
   }
   else  // D3D
   {
diff --git a/Source/Core/VideoCommon/VideoCommon.h b/Source/Core/VideoCommon/VideoCommon.h
index de4f69c9a6..e25b2b66a5 100644
--- a/Source/Core/VideoCommon/VideoCommon.h
+++ b/Source/Core/VideoCommon/VideoCommon.h
@@ -73,6 +73,7 @@ enum class APIType
 {
   OpenGL,
   D3D,
+  Vulkan,
   Nothing
 };