diff --git a/Source/Core/VideoBackends/Vulkan/VulkanContext.cpp b/Source/Core/VideoBackends/Vulkan/VulkanContext.cpp
index c0fca1008c..990e38acec 100644
--- a/Source/Core/VideoBackends/Vulkan/VulkanContext.cpp
+++ b/Source/Core/VideoBackends/Vulkan/VulkanContext.cpp
@@ -346,6 +346,10 @@ void VulkanContext::PopulateBackendInfoFeatures(VideoConfig* config, VkPhysicalD
   // with depth clamping. Fall back to inverted depth range for these.
   if (DriverDetails::HasBug(DriverDetails::BUG_BROKEN_REVERSED_DEPTH_RANGE))
     config->backend_info.bSupportsReversedDepthRange = false;
+
+  // GPU Texture Decoding is broken under MoltenVK.
+  if (DriverDetails::HasBug(DriverDetails::BUG_BROKEN_GPU_TEXTURE_DECODING))
+    config->backend_info.bSupportsGPUTextureDecoding = false;
 }
 
 void VulkanContext::PopulateBackendInfoMultisampleModes(
diff --git a/Source/Core/VideoCommon/DriverDetails.cpp b/Source/Core/VideoCommon/DriverDetails.cpp
index 1670f1a028..3c5d9191c0 100644
--- a/Source/Core/VideoCommon/DriverDetails.cpp
+++ b/Source/Core/VideoCommon/DriverDetails.cpp
@@ -117,7 +117,10 @@ constexpr BugInfo m_known_bugs[] = {
     {API_VULKAN, OS_ALL, VENDOR_ARM, DRIVER_ARM, Family::UNKNOWN, BUG_SLOW_CACHED_READBACK_MEMORY,
      -1.0, -1.0, true},
     {API_VULKAN, OS_ALL, VENDOR_QUALCOMM, DRIVER_QUALCOMM, Family::UNKNOWN,
-     BUG_SLOW_CACHED_READBACK_MEMORY, -1.0, -1.0, true}};
+     BUG_SLOW_CACHED_READBACK_MEMORY, -1.0, -1.0, true},
+    {API_VULKAN, OS_OSX, VENDOR_ALL, DRIVER_PORTABILITY, Family::UNKNOWN,
+     BUG_BROKEN_GPU_TEXTURE_DECODING, -1.0, -1.0, true},
+};
 
 static std::map<Bug, BugInfo> m_bugs;
 
diff --git a/Source/Core/VideoCommon/DriverDetails.h b/Source/Core/VideoCommon/DriverDetails.h
index 3e58a5fb58..59250a4415 100644
--- a/Source/Core/VideoCommon/DriverDetails.h
+++ b/Source/Core/VideoCommon/DriverDetails.h
@@ -286,6 +286,10 @@ enum Bug
   // Mali Vulkan driver, causing high CPU usage in the __pi___inval_cache_range kernel
   // function. This flag causes readback buffers to select the coherent type.
   BUG_SLOW_CACHED_READBACK_MEMORY,
+
+  // BUG: GPU Texture Decoding produces a spectacular mess or just outright crashes when using
+  // Vulkan on macOS through MoltenVK.
+  BUG_BROKEN_GPU_TEXTURE_DECODING,
 };
 
 // Initializes our internal vendor, device family, and driver version